Research and procedures involving animals : Our research integrity : ... : Research at Sussex : �պ��

Research and procedures involving animals

We are committed to meeting or exceeding all external ethical and regulatory requirements for research involving animals.

Research and procedures involving animals

Rats housed in our animal facility, which operates to the highest standards of animal care and welfare. All research is only performed after animal welfare and ethical review has taken place.

Animal research at the �պ��

We are a signatory to the , which aims to help the public understand how and why animals are used on its behalf in scientific, medical and veterinary research in the UK.

Research using animals has made, and continues to make, a vital contribution to the understanding, treatment and cure of major human health problems; including cancer, heart disease, polio, diabetes and neurological diseases and disorders.

While new methods have enabled scientists and medical researchers to reduce studies involving animals, some work must continue for further fundamental advances to be made, but only after weighing the potential benefits of the research against the effects on the animals concerned.

The University's position is set out below:

In the UK, research and teaching activities involving animals considered to be sentient are governed by a range of legislation, including the Animals (Scientific Procedures) Act, 1986 and, in the case of teaching to veterinary students, the Veterinary Surgeons Act 1966. Compliance of research involving these species is monitored by University staff and by the �պ�� Office through its inspectors.
The University is committed to the principles of reduction, refinement and replacement (the 3Rs). On each project it ensures that the number of animals used is minimised and that procedures, care routines and husbandry are refined to maximise welfare.
The University is also committed to the development of a number of alternative methods such as computer modelling, tissue culture, cell and molecular biology, and human clinical research. Animal procedures are replaced with non-animal techniques wherever possible. Where the use of animals remains essential, the �պ�� is committed to a culture of care and respect for animal welfare.

Animal statistics

The �պ��’s statistics on the use of animals in research are returned annually to the �պ�� Office, and are laid out in the tables below.

�պ�� Office Return of Procedures by Species
	2019	2020	2021	2022	2023
Mice	6912	6551	7715	5041	4717
Rats	705	84	190	108	72
Fish	11911	9380	11486	10550	9984
Frogs			12	25	197
Other			23	98	0
Totals	19528	16015	19426	15822	14970

�պ�� Office Return of Procedures by Species %
Species	Numbers used (%)
	2019	2020	2021	2022	2023
Mice	35.4	40.9	39.7	31.9	31.5
Zebrafish	61.0	58.6	59.1	66.7	66.7
Rats	3.6	0.5	1.00	0.7	0.5
Frogs			0.1	0.2	1.3
Other			0.1	0.6	0
Total	100	100	100	99.97	100

�պ�� Office Return of Procedures by Severity
	2019	2020	2021	2022	2023
Sub Threshold	6157	4374	6349	5433	5078
Mild	7872	9301	9271	4311	3366
Moderate	651	475	1408	1224	2663
Severe	315	205	398	267	248
Non-recovery	4533	1660	2000	4587	3615
Totals	19528	16015	19426	15822	14970

The University's Animal Welfare and Ethical Review Body review process

The University's AWERB review process involves lay representation (including a representative from an animal welfare organisation) and other members both external and internal to the University. It provides ethical advice on standards of animal care, welfare and accommodation and ensures that those working with animals are aware of their responsibilities and receive appropriate training. Veterinary and animal care staff are actively involved in the ethical review of research, welfare and care of animals and provide ongoing advice and support to researchers where appropriate.
In the case of animal research proposals, which are not covered by the Animals (Scientific Procedures) Act 1986, the Principle Investigator, or Supervisor (in the case of student projects) is still required to apply for approval through the University's review process.